![]() The true incidence of PE is unknown, but in the United States, it is estimated that nearly a third of hospitalized patients are at risk of developing VTE and up to 600,000 cases of VTE are diagnosed per year with 100,000 deaths related to these diseases. Venous thromboembolism is a major worldwide burden of disease with ∼10 million cases per year and an associated substantial morbidity and mortality. This review focuses on the epidemiology, risk factors, pathophysiology, and natural history of PE. The clinical presentation of acute PE ranges from asymptomatic and incidentally discovered to massive PE causing immediate death. PE results when thrombus migrates from the venous circulation to the pulmonary vasculature and lodges in the pulmonary arterial system. Pulmonary embolism (PE) and deep venous thrombosis (DVT) exist on the spectrum of venous thromboembolic disease (VTE). Physicians should claim only the credit commensurate with the extent of their participation in the activity. Tufts University School of Medicine designates this journal-based CME activity for a maximum of TUSM is accredited by the ACCME to provide continuing medical education for physicians. ![]() This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of Tufts University School of Medicine (TUSM) and Thieme Medical Publishers, New York. Upon completion of this article, the reader will be able to identify the disease burden of pulmonary embolism, as well as the progression of the disease with and without treatment, and potential for long-term disability.
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